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Role of NAD+ in Anti-Aging and Cancer Therapies

Did you know – scientists attempting to improve the aging process have identified multiple compounds that appear to improve aging and promote longevity? 

Nicotinamide adenine dinucleotide, also known as NAD+ is one such molecule that has been added to the list of possible anti-aging and immune booster drugs. 

NAD+ is a critical enzyme found in the cells in our body. It plays an important role in boosting immunity and metabolism. It is also known for its role in preventing age-related health conditions, defective immune response and neurodegeneration properties. 

 According to a scientific research, NAD+ plays a crucial role in enzymatic reactions of the body such as – oxidative phosphorylation, TCA cycle and fatty acid oxidation. It regulates DNA damage repair, energy metabolism, stress response and gene expression. On the other hand, it is a substrate for different signalling enzymes such as cADPRs and PARPs. 

 The human body doesn’t have an endless supply of NAD+. It declines with age. We get NAD from the diet via food made of amino acids. Making healthy food choices can help improve the levels of NAD+. It is not only nutritionally controlled but depends on physical activities and lifestyle factors. 

 Restoration of NAD+ could reverse the phenotype of malignant cells by inducing cellular repair and removal of damaged cells. It is necessary to implement lifestyle approaches that simulate NAD+ levels.

NAD+ and Aging

Aging is characterized by the decline in the regenerative potential of cells and tissues. It causes multiple changes in the body’s metabolism. Several factors accelerate aging by inducing inflammation in cells and tissues. 

With aging, NAD+ levels decrease in cells and important organs like – liver, skin, brain etc. Also, low NAD+ levels are associated with the secretion of insulin. In a study, it was found that nutritional supplementation of NAD+ may reduce insulin resistance.  

 NAD+ depletion is primarily caused by mitochondrial dysfunction, which declines the ROS and produces high oxidative stress. This leads to activation of chronic PARP – resulting in rapid consumption of NAD+. 

 Deterioration of NAD+ contributes to the progression of multiple health conditions including – neurological disorder, cancer, metabolic disorder and so on. 

NAD+ and Cancer

 According to a study, cancer cells rely on glycolysis. The fatty acid synthesis, serine synthesis and pentose phosphate pathway are unregulated in cancer – and require a cofactor NAD+ to support faster energy production. Also, NAD+ is crucial in counteracting ROS production and acts as a building block for tumour proliferation. 

 To respond to the cellular damage in cancer patients, the human body must synthesize NAD+. Extracellular NAD+ can be consumed to fine-tune immune responses and regulate anti-tumour T-cell response. In the same study, NAD+ has been shown to contribute to cellular capacity to tolerate oxidative stress.  

Also, the production of ROS increases as NAD+ declines with age. It promotes the accumulation of hypoxia-inducible factor-1α (HIF-1α) that leads to reprogramming of metabolism and death of healthy cells. 

The role of NAD+ in boosting cellular health has opened up the possibility of using it to kill cancerous cells. Additionally, modulation of NAD+ levels could be important in preventing cancer and other chronic diseases. 

Wellology Bio-Gene NAD+

It is no doubt that cancer and aging are two linked processes. Aging is a risk factor for many types of cancer - as cancer pathogenesis and mechanisms implicated in aging display considerable similarities. 

With the recent advancement in aging and longevity research, scientific evidence claims that NAD+ supplements can promote lifespan. Additionally, NAD+ supplements with Pterostilbene help to prevent age-related genetic changes and restore youthfulness. 

 Wellology’s Bio-Gene NAD+ is a potential supplement with promising therapeutic formulation to promote longevity. Based on the experiments conducted on cell culture and model organisms, supplementing the body with NAD+ can enhance the function of stem cells and help boost overall wellbeing. 


Get started with your daily dose of NAD+ today!